ETRABRAIN EU FP7 - Initial Training Network

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Project Co-ordinator:

Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

Project Manager:

Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

Recruitment Co-ordinator

Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY

Training Co-ordinator

Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK

Publications:

Neuroscience. 2017. [Epub ahead of print] Extracellular matrix alterations in the ketamine model of schizophrenia. Matuszko G, Curreli S, Kaushik R, Becker A, Dityatev A.
Behav Brain Res. 2017. [Epub ahead of print] Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93.Winkler D, Daher F, Wüstefeld L, Hammerschmidt K, Poggi G, Seelbach A, Krueger-Burg D, Vafadari B, Ronnenberg A, Liu Y, Kaczmarek L, Schlüter OM, Ehrenreich H, Dere E.
Biomaterials. 2017. ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals.Ordóñez-Gutiérrez L, Posado-Fernández A, Ahmadvand D, Lettiero B, Wu L, Antón M, Flores O, Moghimi SM, Wandosell F.
Mol Psychiatry. 2016. [Epub ahead of print] All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class.Castillo-Gómez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann WH, Bertrand D, Ehrenreich H, Hollmann M.
J Neurochem. 2016. Epub 2016. MMP-9 in translation: from molecule to brain physiology, pathology, and therapy. Vafadari B, Salamian A, Kaczmarek L.
Neurol Psychiat BR. 2016. Circulating NMDAR1 autoantibodies of different immunoglobulin classes modulate evolution of lesion size in acute ischemic stroke. Ehrenreich H, Castillo-Gómez E, Oliveira B, Ott C, Steiner J, Weissenborn K.
EMBO J. 2016. Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC, Herms J.
Mol Med. 2015. [Epub ahead of print] Widespread expression of erythropoietin receptor in brain and its induction by injury. Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H.
Acta Neuropathol. 2015. Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.Zou C, Montagna E, Shi Y, Peters F, Blazquez-Llorca L, Shi S, Filser S, Dorostkar MM, Herms J.
EMBO Mol Med. 2015. Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H1, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H.
Neuron. 2015. Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca(2+) in Neurons and Astroglia.Zheng K, Bard L, Reynolds JP, King C, Jensen TP, Gourine AV, Rusakov DA.

Publications related to proposed PhD projects

Knapska E., Lioudyno V., Kiryk A., Gorkiewicz T., Mikosz M., Michaluk P., Gawlak M., Chaturvedi M., Mochol G., Balcerzyk M., Wojcik D.K., Wilczynski G.M., Kaczmarek L. Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. J. Neurosci., 33: 14591–14600, 2013.
Dziembowska M., Milek J., Janusz A., Rejmak E., Romanowska E., Gorkiewicz T., Tiron A., Bramham C., Kaczmarek L. Activity-dependent local translation of matrix metalloproteinase-9. J. Neurosci., 32: 14538 –14547, 2012.
Rivera S., Khrestchatisky M., Kaczmarek L., Rosenberg G.A., Jaworski D.M., Metzincin proteases and their inhibitors, foes or friends in nervous system physiology? J. Neurosci., 30: 15337–15357, 2010.
Knapska E., Macias M., Mikosz M., Nowak A., Owczarek D., Wawrzyniak M., Pieprzyk M., Cymerman I.A., Werka T., Sheng M., Maren S., Jaworski J., Kaczmarek L. Functional anatomy of neural circuits regulating fear and extinction. Proc. Natl. Acad. Sci. USA, 42: 17093-17098, 2012.
Knapska E., Radwanska K., Werka T., Kaczmarek L. Functional internal complexity of amygdala: focus on gene activity mapping following behavioral training and drugs of abuse. Physiol. Rev., 87: 1113-1173, 2007.
Wilczynski G.M., Konopacki F.A., Wilczek E., Lasiecka Z., Gorlewicz A., Michaluk P., Wawrzyniak M., Malinowska M., Okulski P., Kolodziej L.R., Konopka W., Duniec K., Mioduszewska B., Nikolaev E., Walczak A., Owczarek D., Gorecki D.C., Zuschratter W., Ottersen O.P., Kaczmarek L. Important role of matrix metalloproteinase 9 (MMP-9) in epileptogenesis. J. Cell Biol., 180: 1021-1035, 2008.
Dityatev & Rusakov (2011) Molecular signals of plasticity at the tetrapartite synapse. Curr Opin Neurobiol. 2011, 21:353-9;
Caiazzo et al. (2011) Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476:224-7;
Dityatev et al. (2010) The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat Rev Neurosci. 11:735-46;
Kochlamazashvili et al. (2010) The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-type Ca2+ channels. Neuron 67:116-28
Bourgognon J-M, Schiavon E, Salah-Uddin H, Skrzypiec AE, Attwood B, Shah RS, Mucha M, Challiss RAJ, Forsythe ID, Pawlak R. Regulation of Neuronal Plasticity and Fear by a Dynamic Change in PAR1 - G Protein Coupling in the Amygdala. Molecular Psychiatry 2013;18(10):1136-45.
Mucha M, Skrzypiec AE, Schiavon E, Attwood BK, Kucerova E, Pawlak R. Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. PNAS 2011, 108(45):18436-41.
Attwood B, Bourgognon J-M, Patel S, Mucha M, Schiavon E, Skrzypiec AE, Young KW, Shiosaka S, Korostynski M, Piechota M, Przewlocki R, UPawlak RU. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature 2011, 473(7347):372-5.
Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J, Rosethorne EM, Charlton SJ, Tobin AB. The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. PNAS 2010, 107(20):9440-9445.
Donato F, Rompani SB, Caroni P. (2013) Parvalbumin basket cell network plasticity induced by experience regulates learning in the adult. Nature, in press.
Caroni P, Donato F, Muller D. (2012) Structural plasticity upon learning: regulation and function. Nat Rev Neurosci. 13:478-90.
Ruediger S, Vittori C, Bednarek E, Genoud C, Strata P, Sacchetti B, Caroni P. (2011) Learning-related feedforward connectivity growth required for memory precision. Nature. 473:514-8.
Bednarek E, Caroni P. (2011) bAdducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron. 69:1132-46.
Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H. (2013) Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry, Epub ahead of print.
El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner H, Pawlak R, Nave KA, Ehrenreich H (2013) A single gene defect causing claustrophobia. Translational Psychiatry, in press
Hagemeyer N, Goebbels S, Papiol S, Kästner A, Hofer S, Begemann M, Gerwig UC, Boretius S, Wieser GL, Ronnenberg A, Gurvich A, Heckers SH, Frahm J, Nave KA_, Ehrenreich H (2012) A myelin gene causative of a catatonia-depression syndrome upon aging. EMBO Mol Med 4:528-39
Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H (2011) A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO Mol Med 3:309-19.
Ribbe K, Ackermann V, Schwitulla J, Begemann M, Papiol S, Grube S, Sperling S, Friedrichs H, Jahn O, Sillaber I, Gefeller O, Krampe H, Ehrenreich H (2011) Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin releasing factor system. Arch Gen Psych 68: 1247-56.
Wüstenberg T, Begemann M, Bartels C, Gefeller O, Stawicki S, Hinze-Selch D, Mohr A, Falkai P, Aldenhoff JB, Knauth M, Nave KA, Ehrenreich H (2011) Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia. Molecular Psychiatry 16: 26-36.
Begemann M, Klaus S, Papiol S, Malzahn D, Krampe H, Ribbe K, Friedrichs H, Radyushkin KA, El-Kordi A, Benseler F, Hannke K, Sperling S, Schwerdtfeger D, Thanhäuser I, Gerchen MF, Ghorbani M, Gutwinski S, Hilmes C, Leppert R, Ronnenberg A, Sowislo J, Stawicki S, Stödtke M, Szuszies C, Reim K, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Ehrenreich H (2010) Complexin2 gene polymorphisms modify cognitive performance in schizophrenia. Arch Gen Psych 67: 879-88.
Burgold, S.; Bittner, T., Dorostkar, M.M.; Kieser, D.; Fuhrmann, M.; Mitteregger, G.; Kretzschmar, H.; Schmidt, B.; Herms, J. (2011) In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta Neuropathol. 121(3):327-35.
Bittner, T; Fuhrmann, M.; Burgold S.; Ochs S.; Hoffmann, N.; Mitteregger, G.; Haass, C.; LaFerla, F.M.; Kretzschmar, H.A.; Herms, J. (2010) Multiple Events lead to dendritic spine loss in triple transgenic Alzheimer’s disease mice. PLoS One. 5(11):e15477
Fuhrmann, M.; Bittner, T.; Jung, C.K.E.; Burgold, S.; Page, R.M.; Mitteregger, G.; Haass, C.; LaFerla, F.M.; Kretzschmar, H.A.; Herms, J. (2010) Microglia CX3CR1 knockout prevents neuron loss in an Alzheimer`s disease mouse model. Nature Neurosci. 13:411-413
Bittner T., Fuhrmann M., Burgold S., Jung C.K.E., Volbracht C., Steiner H., Mitteregger G., Kretzschmar H. A., Haass C., Herms J. (2009) Gamma-Secretase inhibition reduces spine density in vivo via an APP-dependent pathway. J. Neurosci. 29:10405-10409.
Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites. Specht CG, Izeddin I, Rodriguez PC, El Beheiry M, Rostaing P, Darzacq X, Dahan M, Triller A. Neuron. 2013 Jul 24;79(2):308-21.
Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons. Hennekinne L, Colasse S, Triller A, Renner M. J Neurosci. 2013 Jul 10;33(28):114329.
Synaptic structure and function. Triller A, Sheng M. Curr Opin Neurobiol. 2012 Jun;22(3):3635.
A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses. Charrier C, Machado P, Tweedie-Cullen RY, Rutishauser D, Mansuy IM, Triller A. Nat Neurosci. 2010 Nov;13(11):1388-95.
Markoutsa E, Papadia K, Clemente C, Flores O, Antimisiaris SG, 2012: Anti-Aβ-MAb and dually decorated nanoliposomes: effect of Aβ1-42 peptides on interaction with hCMEC/D3 cells, Eur J Pharm Biopharm, May;81(1):49-56.
Canovi M, Markoutsa E, Lazar AN, Pampalakis G,Clemente C, Re F, Sesana S, Masserini M, Salmona M, Duyckaerts C, Flores O, Gobbi M, Antimisiaris SG, 2011: The binding affinity of anti-A_1-42 MAb-decorated nanoliposomes to A_1-42 peptides in vitro and to amyloid deposits in post-mortem tissue, Biomaterials, Aug;32(23):5489-97.
Le Droumaguet B, Nicolas J, Brambilla D, Mura S, Maksimenko A, De Kimpe L, Salvati E, Zona C, Airoldi C, Canovi M, Gobbi M, Magali N, La Ferla B, Nicotra F,Scheper W, Flores O, Masserini M, Andrieux K, Couvreur P, 2012: Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease, ACS Nano., Jul 24;6(7):5866-79.