Project Co-ordinator:
Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND
Project Manager:
Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND
Recruitment Co-ordinator
Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY
Training Co-ordinator
Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK
1- Kick off meeting : Practical workshop of the optical methods for studyingthe nervous system in École Normale Supérieure.Paris, France. (March 2014)
In this meeting ESRs introduced themselves and previous works to PIs in a 10 minute talk.
2- Advanced Training Course : Molecules, cells and behavior; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. (October 2014)
Oral Presentations titles :
Behnam Vafadari
MK-801-induced hyperlocomotion in mice with altered levels of MMP-9 is attenuated by clozapine
Ahmad Salamian
MMP-9 in Amygdala-Dependent Learning and Synaptic Plasticity
Gabriela Matuszko:
ECM-mediated regulation of GABAergic transmission and schizophrenia
Maura Ferrer Ferrer:
Neurotrypsin and mental retardation
Alberto Labrador-Ramos:
The role of cleavage of EphA4 by tPA/plasmin in brain physiology and pathology
Barbara Oliveira:
Molecular and Cellular Underpinnings of Autistic Phenotypes
Elena Montagna
Amyloid Precursor Protein (APP) and its involvement in neuronal activity. A calcium imaging study of neurons layer 3/2 of the somatosensory cortex of mice lacking APP
Alexandra Nothnagel
Extracellular matrix and synapse dynamics - single molecule and super-resolution imaging : powerful tools to assess the dynamics of ECM components and receptors at synapses
Adrian Posado Fernandez:
Thesis plan presentation
3- Practical workshop: Behavioral techniques in rodents and Symposium on Emotional Brain NENCKI institute, Warsaw, Poland. (May 2015)
Poster Presentations titles :
Behnam Vafadari
Behavioral characterization of maleheterozygous PSD-95 deficient mice
Ahmad Salamian
The Effect of Matrix Metalloproteinases on Presynaptic Vesicle Recycling
Gabriela Matuszko:
Visualization and sub-cellular targeting of neural extracellular matrix
Maura Ferrer Ferrer:
Neurotrypsin-dependent synaptic plasticity, learning and spinogenesis
Alberto Labrador-Ramos:
Crosstalk between Eph/ephrin system and proteolyisis in the mouse brain
Barbara Oliveira:
In vitro modelling of Neuropsychiatric disorders
Elena Montagna
The role of Amyloid Precursor Protein in neuronal acitvity
Alexandra Nothnagel
Neocortical neuron cultures to study the function of perineuronal nets in synaptic plasticity
Adrian Posado Fernandez:
Production and molecular characterization of STAB VIDA-MAb
4- Advanced Training course: German Center for Neurodegenerative Diseases (DZNE) Munich, Germany. (October 2015)
Oral Presentations titles :
Behnam Vafadari
MMP-9 in learning and schizophrenia-like behavior in rodents
Ahmad Salamian
MMP-9 in Presynaptic Plasticity?
Gabriela Matuszko:
ECM-mediated regulation of GABAergic transmission and schizophrenia
Maura Ferrer Ferrer:
Neurotrypsin-dependent synaptic plasticity, learning and spinogenesis
Alberto Labrador-Ramos:
PAR-1 "ECM signalosome" and fear/anxiety
Barbara Oliveira:
Circulating NMDAR autoantibodies
Elena Montagna
In depth analysis of APP (Amyloid Precursor Protein): implication in spine morphology
Alexandra Nothnagel
Extracellular matrix and synaptic plasticity - Effect of OTX2 on synaptic densities and parvalbumin expression
Adrian Posado Fernandez:
Molecular characterization of STAB VIDA MAb and presentation of the first preclinical assay in mice
5- Practical workshop : electrophysiology and combinatorial techniques German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. (March 2016)
In this meeting ESRs talked about the project advances and their scientific achievments.
6- The Inner Workings of a Molecular Brain organized by Exeter university, Santorini, Greece. (October 2016)
Oral Presentations titles :
Behnam Vafadari
Role of MMP-9 in schizophrenia-like behaviors in rodents
Ahmad Salamian
Role of MMP-9 in a cholinergicalley induced plasticity at hippocampal synapses
Gabriela Matuszko:
ECM-mediated regulation of GABAergic transmission and schizophrenia
Maura Ferrer Ferrer:
Neurotrypsin-dependent synaptic plasticity, learning and spinogenesis
Alberto Labrador-Ramos:
The role of cleavage of EphA4 by tissue plasminogen activator / plasmin cascade in brain physiology and pathology
Elena Montagna
Amyloid precursor protein: an insight to its physiological functions and to its functional domains
Alexandra Nothnagel
Extracellular matrix and synaptic plasticity - Consequences of general activity modulation of the network on OTX2 induced changes in cortical cultures
Adrian Posado Fernandez:
Presentation of the results of the first preclinical assay in mice
Other workshops and confrences of ESRs
Behnam Vafadari
1- ECMNET COST Meeting, Brain Extracellular Matrix in Health and Disease. Antalya, Turkey. September 2014
Presentation: MK-801-induced hyperlocomotion in micewith altered levels of MMP-9 is attenuated by clozapine
2- Embo Conference, Brain imaging, Nencki instituteof experimental biology, Warsaw, Poland. May 2016
Presentation: Visualization of dendritic spines targeted bybasolateral amygdala axonal projections
3- 10th FENS Forum of Neuroscience, Copenhagen, Denmark. July 2016
Presentation: Altered levels of MMP-9 cause sex-dependentbehavioral effects in schizophrenia-related behaviors in mice
4- The malleable brain: plasticity of neural circuits andbehavior workshop by Neurochemistry society (ISN). Alpbach, Austria. September 2016
Ahmad Salamian
1- The Effect of Matrix Metalloproteinases on Presynaptic Vesicle Recycling. (July 2-3, 2015). EMBO Young Scientists Forum, Warsaw, Poland.
2- Possible prominent role for matrix metalloproteinases (MMPs) in regulation of presynaptic release probability. (May 18-21, 2016). Imaging the Brain Conference, Warsaw, Poland.
3- Matrix metalloproteinase-9 (MMP-9) activity might prominently regulate presynaptic release probability. (June 1-4, 2016). 7th ISN Special Neurochemistry Conference, Coimbra, Portugal.
4- Presynaptic release probability might be regulated prominently by activity of matrix metalloproteinases. (July 2-6, 2016). 10th FENS forum of Neuroscience, Copenhagen, Denmark.
5- The malleable brain: plasticity of neural circuits andbehavior workshop. (September 12-18, 2016). ISN-JNC Flagship School, Alpbach, Austria.
Maura Ferrer Ferrer:
1- 4th LIN Symposium: Synaptic function and synaptic pathology in disease (August 25th – 28th 2014, Tangermünde, Germany): attendance and poster presentation.
2- 10th FENS Forum of Neuroscience (July 2nd – July 6th 2016 , Copenhagen, Denmark): attendance and poster presentation.
Barbara Oliveira:
Schizophrenia Workshop organized by Clinical Neuroscience, Max Planck Institute of Experimental Medicine, lecture: “Neuropathology and histology of Schizophrenia” and practical module “Cell culture methods” (2014; 2015; 2016)