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ETRABRAIN EU FP7 - Initial Training Network | ESR7

Project Co-ordinator:

Prof. Leszek Kaczmarek
Nencki Institute
Warsaw, POLAND


Project Manager:

Ms. Marta Rucinska
Nencki Institute
Warsaw, POLAND


Recruitment Co-ordinator

Prof. Alexander Dityatev
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY


Training Co-ordinator

Prof. Robert Pawlak
University of Exeter Medical School
Exeter, UK

ESR7:    MMP-9 and synaptogenesis upon learning in the hippocampus (lead: FMI, partners: NENCKI)

Matteo Tripodi         












This project will address the mechanisms relating learning-related shifts in PV basket cell differentiation to synapse turnover and memory consolidation. One key aspect will involve the role of extracellular matrix remodeling in the regulation of synapse dynamics, particularly so-called perineuronal nets. The project requires an interest in relating the mechanisms regulating the plasticity of local neuronal microcircuits in the hippocampus to specific aspects of behavior and learning in mice. We will use pharmacogenetic manipulation of defined neurons in vivo, neuroanatomy, mouse genetics and behavioral assays.

The Caroni team has a long-standing interest in the mechanisms of adult structural and functional plasticity in the hippocampal circuits.

For more information about research in the group, please see recent papers and reviews:

  • Donato F, Rompani SB, Caroni P. (2013) Parvalbumin basket cell network plasticity induced by experience regulates learning in the adult. Nature, in press.
  • Caroni P, Donato F, Muller D. (2012) Structural plasticity upon learning: regulation and function. Nat Rev Neurosci. 13:478-90.
  • Ruediger S, Vittori C, Bednarek E, Genoud C, Strata P, Sacchetti B, Caroni P. (2011) Learning-related feedforward connectivity growth required for memory precision. Nature. 473:514-8.
  • Bednarek E, Caroni P. (2011) bAdducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron. 69:1132-46.


The FMI (www.fmi.ch) is at the interface of academic research and biomedical application and contributes to the development of both diagnostics and medicines. FMI students are exposed to the latest molecular and genetic approaches, and are constantly encouraged to examine the biomedical application of their discoveries.

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