Project Co-ordinator:

Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Project Manager:

Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Recruitment Co-ordinator

Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY

 

Training Co-ordinator

Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK

1- Kick off meeting : Practical workshop of the optical methods for studyingthe nervous system in École Normale Supérieure.Paris, France. (March 2014)

 

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In this meeting ESRs introduced themselves and previous works to PIs in a 10 minute talk.

 

2- Advanced Training Course : Molecules, cells and behavior; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. (October 2014)

 


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Oral Presentations titles :

Behnam Vafadari

 MK-801-induced hyperlocomotion in mice with altered levels of MMP-9 is attenuated by clozapine

Ahmad Salamian

MMP-9 in Amygdala-Dependent Learning and Synaptic Plasticity

Gabriela Matuszko:

ECM-mediated regulation of GABAergic transmission and schizophrenia

Maura Ferrer Ferrer:

Neurotrypsin and mental retardation

Alberto Labrador-Ramos:

The role of cleavage of EphA4 by tPA/plasmin in brain physiology and pathology

Barbara Oliveira:

Molecular and Cellular Underpinnings of Autistic Phenotypes

Elena Montagna  

Amyloid Precursor Protein (APP) and its involvement in neuronal activity. A calcium imaging study of neurons layer 3/2 of the somatosensory cortex of mice lacking APP

Alexandra Nothnagel

Extracellular matrix and synapse dynamics - single molecule and super-resolution imaging : powerful tools to assess the dynamics of ECM components and receptors at synapses

Adrian Posado Fernandez:

Thesis plan presentation

3- Practical workshop: Behavioral techniques in rodents and Symposium on Emotional Brain NENCKI institute, Warsaw, Poland. (May 2015)

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Poster Presentations titles :

Behnam Vafadari

Behavioral characterization of maleheterozygous PSD-95 deficient mice

Ahmad Salamian

 The Effect of Matrix Metalloproteinases on Presynaptic Vesicle Recycling

Gabriela Matuszko:

Visualization and sub-cellular targeting of neural extracellular matrix

Maura Ferrer Ferrer:

Neurotrypsin-dependent synaptic plasticity, learning and spinogenesis

Alberto Labrador-Ramos:

Crosstalk between Eph/ephrin system and proteolyisis in the mouse brain

Barbara Oliveira:

In vitro modelling of Neuropsychiatric disorders

Elena Montagna 

The role of Amyloid Precursor Protein in neuronal acitvity

Alexandra Nothnagel

Neocortical neuron cultures to study the function of perineuronal nets in synaptic plasticity

Adrian Posado Fernandez:

Production and molecular characterization of STAB VIDA-MAb

4- Advanced Training course:  German Center for Neurodegenerative Diseases (DZNE) Munich, Germany. (October 2015)

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Oral Presentations titles :

Behnam Vafadari

MMP-9 in learning and schizophrenia-like behavior in rodents

Ahmad Salamian

MMP-9 in Presynaptic Plasticity?

Gabriela Matuszko:

ECM-mediated regulation of GABAergic transmission and schizophrenia

Maura Ferrer Ferrer:

Neurotrypsin-dependent synaptic plasticity, learning and spinogenesis

Alberto Labrador-Ramos:

PAR-1 "ECM signalosome" and fear/anxiety

Barbara Oliveira:

Circulating NMDAR autoantibodies

Elena Montagna 

In depth analysis of APP (Amyloid Precursor Protein): implication in spine morphology       

Alexandra Nothnagel

Extracellular matrix and synaptic plasticity - Effect of OTX2 on synaptic densities and parvalbumin expression

Adrian Posado Fernandez:

Molecular characterization of STAB VIDA MAb and presentation of the first preclinical assay in mice

5- Practical workshop : electrophysiology and combinatorial techniques German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. (March 2016)

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In this meeting ESRs talked about the project advances and their scientific achievments.

 

6- The Inner Workings of a Molecular Brain organized by Exeter university, Santorini, Greece. (October 2016)

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Oral Presentations titles :   

Behnam Vafadari

Role of MMP-9 in schizophrenia-like behaviors in rodents

Ahmad Salamian

Role of MMP-9 in a cholinergicalley induced plasticity at hippocampal synapses

Gabriela Matuszko:

ECM-mediated regulation of GABAergic transmission and schizophrenia

Maura Ferrer Ferrer:

Neurotrypsin-dependent synaptic plasticity, learning and spinogenesis

Alberto Labrador-Ramos:

The role of cleavage of EphA4 by tissue plasminogen activator / plasmin cascade in brain physiology and pathology

Elena Montagna 

Amyloid precursor protein: an insight to its physiological functions and to its functional domains       

Alexandra Nothnagel

Extracellular matrix and synaptic plasticity - Consequences of general activity modulation of the network on OTX2 induced changes in cortical cultures

Adrian Posado Fernandez:

Presentation of the results of the first preclinical assay in mice

 

Other workshops and confrences of ESRs

Behnam Vafadari

1- ECMNET COST Meeting, Brain Extracellular Matrix in Health and Disease. Antalya, Turkey. September 2014

Presentation: MK-801-induced hyperlocomotion in micewith altered levels of MMP-9 is attenuated by clozapine

2- Embo Conference, Brain imaging, Nencki instituteof experimental biology, Warsaw, Poland. May 2016

Presentation: Visualization of dendritic spines targeted bybasolateral amygdala axonal projections

3- 10th FENS Forum of Neuroscience, Copenhagen, Denmark. July 2016 

Presentation: Altered levels of MMP-9 cause sex-dependentbehavioral effects in schizophrenia-related behaviors in mice

4- The malleable brain: plasticity of neural circuits andbehavior workshop by Neurochemistry society (ISN). Alpbach, Austria. September 2016

Ahmad Salamian

1- The Effect of Matrix Metalloproteinases on Presynaptic Vesicle Recycling. (July 2-3, 2015). EMBO Young Scientists Forum, Warsaw, Poland.

2- Possible prominent role for matrix metalloproteinases (MMPs) in regulation of presynaptic release probability. (May 18-21, 2016). Imaging the Brain Conference, Warsaw, Poland.

3- Matrix metalloproteinase-9 (MMP-9) activity might prominently regulate presynaptic release probability. (June 1-4, 2016). 7th ISN Special Neurochemistry Conference, Coimbra, Portugal.

4- Presynaptic release probability might be regulated prominently by activity of matrix metalloproteinases. (July 2-6, 2016). 10th FENS forum of Neuroscience, Copenhagen, Denmark.

5- The malleable brain: plasticity of neural circuits andbehavior workshop. (September 12-18, 2016). ISN-JNC Flagship School, Alpbach, Austria.

Maura Ferrer Ferrer:

1- 4th LIN Symposium: Synaptic function and synaptic pathology in disease (August 25th – 28th 2014, Tangermünde, Germany): attendance and poster presentation.

2- 10th FENS Forum of Neuroscience (July 2nd – July 6th 2016 , Copenhagen, Denmark): attendance and poster presentation.

Barbara Oliveira:

Schizophrenia Workshop organized by Clinical Neuroscience, Max Planck Institute of Experimental Medicine, lecture: “Neuropathology and histology of Schizophrenia” and practical module “Cell culture methods” (2014; 2015; 2016)