ESR1
    ESR2
    ESR3
    ESR4
    ESR5
    ESR6
    ESR7
    ESR8
    ESR9
    ESR10
    ESR11
    ER1
    ER2
    ER3


Project Co-ordinator:

Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Project Manager:

Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Recruitment Co-ordinator

Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY

 

Training Co-ordinator

Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK

ESR7:    MMP-9 and synaptogenesis upon learning in the hippocampus (lead: FMI, partners: NENCKI)

Matteo Tripodi         

matteo.tripodi@fmi.ch

Mateo.jpg

 

 

 

 

 

 

 

 

 

This project will address the mechanisms relating learning-related shifts in PV basket cell differentiation to synapse turnover and memory consolidation. One key aspect will involve the role of extracellular matrix remodeling in the regulation of synapse dynamics, particularly so-called perineuronal nets. The project requires an interest in relating the mechanisms regulating the plasticity of local neuronal microcircuits in the hippocampus to specific aspects of behavior and learning in mice. We will use pharmacogenetic manipulation of defined neurons in vivo, neuroanatomy, mouse genetics and behavioral assays.

The Caroni team has a long-standing interest in the mechanisms of adult structural and functional plasticity in the hippocampal circuits.

For more information about research in the group, please see recent papers and reviews:
 

  • Donato F, Rompani SB, Caroni P. (2013) Parvalbumin basket cell network plasticity induced by experience regulates learning in the adult. Nature, in press.
  • Caroni P, Donato F, Muller D. (2012) Structural plasticity upon learning: regulation and function. Nat Rev Neurosci. 13:478-90.
  • Ruediger S, Vittori C, Bednarek E, Genoud C, Strata P, Sacchetti B, Caroni P. (2011) Learning-related feedforward connectivity growth required for memory precision. Nature. 473:514-8.
  • Bednarek E, Caroni P. (2011) bAdducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron. 69:1132-46.

 

The FMI (www.fmi.ch) is at the interface of academic research and biomedical application and contributes to the development of both diagnostics and medicines. FMI students are exposed to the latest molecular and genetic approaches, and are constantly encouraged to examine the biomedical application of their discoveries.