ESR1
    ESR2
    ESR3
    ESR4
    ESR5
    ESR6
    ESR7
    ESR8
    ESR9
    ESR10
    ESR11
    ER1
    ER2
    ER3


Project Co-ordinator:

Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Project Manager:

Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Recruitment Co-ordinator

Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY

 

Training Co-ordinator

Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK

ESR1:    Role of Matrix Metalloproteinase-9 (MMP-9) in schizophrenia-like behaviors (lead: NENCKI, partners: UNEXE, ETEC)

 Behnam Vafadari

  b.vafadari@nencki.gov.pl

  extra_ben.jpg

The project aims to investigate links between extracellular protease, MMP-9 and schizophrenia. MMP-9 has recently been implicated in the synaptic plasticity as well as neuropsychiatric disorders. In particular, gene polymorphisms, blood plasma protein levels and gene expression response to anti-psychotics  support possible involvement of MMP-9 in schizophrenia. The project will involve extensive behavioral studies on rats and mice, combined with such methods as optogenetics, connectomics, imaging and molecular biology.

We believe that is is possible to localize specific mind functions into the brain and then reveal their molecular and cellular underpinnings. The window to understand mind is learning and memory that can be successfully studied in experimental animals. At the molecular and cellular levels, synaptic plasticity appears to provide plausible explanation for those phenomena.


For more information about research in the group, please see recent papers and reviews:

  • Knapska E., Lioudyno V., Kiryk A., Gorkiewicz T., Mikosz M., Michaluk P., Gawlak M., Chaturvedi M., Mochol G., Balcerzyk M., Wojcik D.K., Wilczynski G.M., Kaczmarek L. Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. J. Neurosci., 33: 14591–14600, 2013.
  • Dziembowska M., Milek J., Janusz A., Rejmak E., Romanowska E., Gorkiewicz T., Tiron A., Bramham C., Kaczmarek L. Activity-dependent local translation of matrix metalloproteinase-9. J. Neurosci., 32: 14538 –14547, 2012.
  • Rivera S., Khrestchatisky M., Kaczmarek L., Rosenberg G.A., Jaworski D.M., Metzincin proteases and their inhibitors, foes or friends in nervous system physiology? J. Neurosci., 30: 15337–15357, 2010.
  • Knapska E., Macias M., Mikosz M., Nowak A., Owczarek D., Wawrzyniak M., Pieprzyk M.,  Cymerman I.A., Werka T., Sheng M., Maren S., Jaworski J., Kaczmarek L. Functional anatomy of neural circuits regulating fear and extinction. Proc. Natl. Acad. Sci. USA, 42: 17093-17098, 2012.
  • Knapska E., Radwanska K., Werka T., Kaczmarek L. Functional internal complexity of amygdala: focus on gene activity mapping following behavioral training and drugs of abuse. Physiol. Rev., 87: 1113-1173, 2007.
  • Wilczynski G.M., Konopacki F.A., Wilczek E., Lasiecka Z., Gorlewicz A., Michaluk P., Wawrzyniak M., Malinowska M., Okulski P., Kolodziej L.R., Konopka W., Duniec K., Mioduszewska B., Nikolaev E., Walczak A., Owczarek D., Gorecki D.C., Zuschratter W., Ottersen O.P., Kaczmarek L. Important role of matrix metalloproteinase 9 (MMP-9) in epileptogenesis. J. Cell Biol., 180: 1021-1035, 2008.

The Nencki Institute (www.nencki.gov.pl) is the leading biological research insitution in Poland, with excellent infrastructure allowing to conduct mostly animal studies ranging from biochemistry & molecular biology through cell biology, neurobiology to neurophysiology, as well as human psychophysiology and brain imaging.