ESR1
    ESR2
    ESR3
    ESR4
    ESR5
    ESR6
    ESR7
    ESR8
    ESR9
    ESR10
    ESR11
    ER1
    ER2
    ER3


Project Co-ordinator:

Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Project Manager:

Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Recruitment Co-ordinator

Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY

 

Training Co-ordinator

Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK

ER2:       Automated imaging platform to investigate the role of ECM on synapse number and function (lead: ETEC, partners: UCL, DZNE-2a, FMI, UNEXE)

Dr. Liesbeth Micholt

liesbeth.micholt@evotec.com

Liesbeth.jpg

 

 

 

 

 

 

Before new medication can be applied to patients an extensive drug discovery process needs to be completed. In the initial steps of this process, it is important to know which molecules can be targeted and how the function of these molecules can change when a drug candidate is applied. Here, high throughput screens, where over 100 000 compounds are tested, are extremely important to make a first selection of relevant drug candidates. These screens are performed on cells grown in specialized conditions.

This project aims to find new drugs to treat brain disorders, such as Alzheimer’s disease, by growing specific brain cells known as neurons. These cells form specialized connections called synapses. The specific objective of this project is to use state-of-the-art imaging techniques to investigate how these synapses are generated, as this forms the basis of memory and learning. In effect, Evotec uses high resolution digital microscopy to measure the numbers and types of connections, or synapses, made between neurons. In diseased brain, these connections are often faulty or absent altogether. The ultimate goal is to use these measurements to screen and identify drugs capable of modifying these connections in a way which might be beneficial for the patient.