ESR1
    ESR2
    ESR3
    ESR4
    ESR5
    ESR6
    ESR7
    ESR8
    ESR9
    ESR10
    ESR11
    ER1
    ER2
    ER3


Project Co-ordinator:

Prof. Leszek Kaczmarek
http://neurogene.nencki.gov.pl
l.kaczmarek@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Project Manager:

Ms. Marta Rucinska
m.rucinska@nencki.gov.pl
Nencki Institute
Warsaw, POLAND

 

Recruitment Co-ordinator

Prof. Alexander Dityatev
alexander.dityatev@dzne.de
Deutsches Zentrum fur
Neurodegenerative Erkrankungen
Magdeburg, GERMANY

 

Training Co-ordinator

Prof. Robert Pawlak
R.Pawlak@exeter.ac.uk
University of Exeter Medical School
Exeter, UK

ER1:       Signal exchange between the ECM and astrocytes (lead: UCL, partners: NENCKI, UNEXE, DZNE-2a)

Dr. James Reynolds

james.reynolds@ucl.ac.uk

James.jpg

 

 

 

 

 

 

 

Astroglia are the most common type of nonneuronal cell, or glial cell, in the brain. Traditionally thought of as supportive cells for maintaining neuronal function in the brain, recent
investigations have revealed that astroglia actively contribute to information processing in the brain, communicating within astroglial networks through calcium waves, or with neurons and other cells of the brain by the release of chemical gliotransmitters.


Astroglia are highly heterogeneous and exhibit structural and functional plasticity in response to
many physiological and experimental stimulations. It is likely that such functions depend on an active, ongoing communication mechanism between astroglia and the extracellular matrix, a communication avenue that is relatively understudied. Using both lifetime and intensity based calcium imaging techniques, we have successfully measured subcellular calcium activity in astroglia, in both brain slices and within the intact brain, as a measure of ongoing signal integration. We are currently pursuing means of imaging and manipulating various constituents of the extracellular matrix to investigate coordination of this astroglia calcium signaling and ECM activity/structure in vivo , in hope of shedding light on a novel and potentially important mode of signalling in the brain.